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. 2011 Nov 23;6(11):e28068. doi: 10.1371/journal.pone.0028068

Figure 5. Regulation of MCF-7 mammosphere formation by breast cancer promoters and metformin.

Figure 5

(A) TCDD increased proliferation of MCF-7 cells in a dose responsive manner (upper), however, BPA did not (middle). On the other hand, metformin treatment decreased MCF-7 proliferation (mean ± SD, n = 3). *, P<0.05; **, P<0.01; ***, P<0.001. (B, C) Metformin further decreased the size (B) and the number (C) of MCF-7 mammosphere formation enhanced by E2, TCDD or BPA (mean ± SD, n = 3). The magnification was X 200. Scale bar represents 50 µm in length. *, P<0.05; **, P<0.01; ***, P<0.001.