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. 2011 Aug 10;85(6):1175–1182. doi: 10.1095/biolreprod.111.091728

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© 2011 by the Society for the Study of Reproduction, Inc.

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FIG. 2. — Transplanted Grem1^−/− ovaries display mature follicles and contain luteinized structures not found in control ovaries. A, B) Gross morphology of neonatal control (A) and Grem1^−/− (B) ovaries (Ov) 3 wk posttransplantation under the kidney (K) capsule of ovariectomized adult recipient mice. C, D) Histological assessment of control (C) and Grem1^−/− (D) transplanted ovaries reveal follicles at all stages of development. Mature antral follicles (AnF) are present in both genotypes. Interestingly, only Grem1^−/− (D) ovaries display luteinized structures (L), suggesting that they are more advanced than control (C) ovaries. E, F) Immunoreactivity for anti-Müllerian hormone (AMH) confirms normal positive staining patterns in secondary follicles (SF) and loss of the protein in the more advanced antral follicles (AnF) and luteinized structures in both wild-type (E) and Grem1^−/− (F). Bars in A and B = 1 mm; bars in C–H = 100 μm.