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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2011 Oct 10;46(6):527–547. doi: 10.3109/10409238.2011.618113

Figure 1. Schematic structure of human mTORprotein.

Figure 1

Human mTOR is a 2549 amino acid protein. It contains multiple HEAT repeats, a helix turn helix (HTH) motif, and a Golgi/ER localization signal sequence (LS) at its N-terminus. Its catalytic domain is flanked by a FAT and FATC sequences. Immediate upstream to the catalytic domain is the FKBP12-rapamycin binding (FRB) motif. A phosphomimetic residue Asp (E2363) at its putative activation loop, three known phosphorylation sites, T2446, S2448, and S2481, and three other less characterized phosphorylation sites, S1261, S2159, T2164, are shown.