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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2011 Oct 10;46(6):527–547. doi: 10.3109/10409238.2011.618113

Figure 2. Two mTOR complexes in activation of AGC kinases and cellular functions.

Figure 2

In response to amino acids and growth factors, mTORC1 and mTORC2 phosphorylate several AGC kinases at conserved motifs in their carboxyl-terminal tail. Phosphorylation at these sites, in conjunction with PDK1 phosphorylation of the AGC kinase activation loop, confers optimal activities to these kinases. In turn, the activated AGC kinases could serve to positively or negatively regulate mTORC signaling to control various cellular functions as indicated.