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. Author manuscript; available in PMC: 2012 Dec 1.

Published in final edited form as: Crit Rev Biochem Mol Biol. 2011 Oct 10;46(6):527–547. doi: 10.3109/10409238.2011.618113

Table 2.

Putative and known AGC kinase substrates of mTORC and non-mTORC

Substrates	Phosphorylation sites	AGC kinases
mTOR	RSRTRT2⁴⁴⁶DS²⁴⁴⁸YS	S6K
	PESIHS²⁴⁸¹FIGDG(*)	S6K, (mTOR)
	KKLHVS¹²⁶¹TINLQ(**)	ND
Raptor	RLRS⁷¹⁹VS721S⁷²²YG	Rsk, S6K
Rictor	RIRTLT¹¹³⁵EPSVD	S6K, SGK, Akt
PRAS40	RPRLNT²⁴⁶SDF	Akt
elF4B	RSRTGS⁴²²ESS	S6K, Rsk
eEF2K	RVRTLSS³⁶⁶GSR	S6K, Rsk
p27^Kip1	KPGLRRRQT¹⁹⁸	Akt, Rsk, SGK
FOXO1	RPRSCT²⁴WPL	Akt, SGK
PDCD4	RLRKNS⁶⁷SRDS⁷¹GRGDS⁷⁶VS	S6K
GSK3a	RARTSS²¹FAE	Akt, Rsk, S6K
S6	RRRLS²³⁵S²³⁶LRAS²⁴⁰TSKS²⁴⁴E	S6K
TSC2	RARSTS⁹³⁹LNE	Akt, Rsk
	RARSTS LNE RCRSIS⁹⁸¹VSE	Akt
	RDRVRS¹¹³⁰MS¹¹³²GGH	Akt
	RPRGYT¹⁴⁶²ISD	Akt, Rsk
	RKRLIS¹⁷⁹⁸SVE	Rsk
	RVVS¹³⁶⁴SEGGRP	PKC
IRS1	RKPKS²⁴MHK	PKCa
	RPRSKS²⁶⁵QS²⁶⁷SS	S6K
	RSRTES³⁰²ITATS³⁰⁷PAS	S6K
	GGKPGS³¹⁸FRVR	aPKCζ
	MSRPAS³³⁶VDGS	cPKCβII
	RHRGS³⁵⁷SRL	nPKCδ
	GYMPMS⁶¹²PGVA	S6K, (mTOR)
	GDYMPMS⁶³²PKSV	S6K, (mTOR)
	RRRHSS¹¹⁰¹ETF (H.S.)	S6K, nPKCθ