Table 2.
Hepatic Porphyrins in Cyp1a2−/−, Hfe−/−, and Urod+/− Mice After Treatment Regimens Consisting Variously of High Iron Diet, Iron-dextran and PCB injections and δ-Aminolevulinic acid-containing Drinking Water
| PORPHYRIN | mouse | HEPATIC PORPHYRINS (nmol/g liver) | |||
|---|---|---|---|---|---|
| Treatment 2 | Treatment 3 | Treatment 4 | Treatment 5 | ||
| Fe-diet | Fe-diet fedex/ala | Fe-diet ala/pcb | Fe-diet fedex/ala/pcb | ||
| URO | #1 | 0.28 | 136.38 | 85.73 | 248.71 |
| #2 | 0.24 | 34.97 | 9.57 | 30.07 | |
| #3 | 0.14 | 8.47 | 8.82 | 3.36 | |
| #4 | 0.22 | 2.85 | 2.90 | 1.02 | |
| #5 | 1.60 | 1.33 | |||
| #6 | 0.77 | 0.65 | |||
| HEPTACARBOXYL | #1 | 0.43 | 60.16 | 30.99 | 86.72 |
| #2 | 0.30 | 19.82 | 1.96 | 9.33 | |
| #3 | 0.41 | 4.17 | 1.99 | 1.01 | |
| #4 | 0.26 | 1.96 | 0.73 | 0.59 | |
| #5 | 0.67 | 0.36 | |||
| #6 | 0.82 | 0.40 | |||
| HEXACARBOXYL | #1 | 0.00 | 2.39 | 1.02 | 2.96 |
| #2 | 0.08 | 0.96 | 0.13 | 0.35 | |
| #3 | 0.00 | 0.21 | 0.15 | 0.09 | |
| #4 | 0.06 | 0.09 | 0.15 | 0.08 | |
| #5 | 0.05 | 0.08 | |||
| #6 | 0.10 | 0.08 | |||
| PENTACARBOXYL | #1 | 0.00 | 0.20 | 0.14 | 0.34 |
| #2 | 0.00 | 0.12 | 0.00 | 0.05 | |
| #3 | 0.00 | 0.06 | 0.00 | 0.00 | |
| #4 | 0.00 | 0.00 | 0.00 | 0.00 | |
| #5 | 0.00 | 0.00 | |||
| #6 | 0.00 | 0.00 | |||
| COPRO | #1 | 0.00 | 0.97 | 0.42 | 1.42 |
| #2 | 0.00 | 0.41 | 0.07 | 0.17 | |
| #3 | 0.00 | 0.14 | 0.10 | 0.03 | |
| #4 | 0.00 | 0.16 | 0.04 | 0.10 | |
| #5 | 0.06 | 0.00 | |||
| #6 | 0.00 | 0.00 | |||
Mice fed a high iron diet (fe-diet, 2 mg Fe/g) after weaning > 14 weeks and were sacrificed 4 weeks after receiving any of additional treatments indicated. “Fedex” was a single injection of aqueous iron dextran (10 mg, ip), “ala” was δ-aminolevulinic acid (2 mg/ml) provided continuously in the drinking water and “pcb” was a single injection of Aroclor 1254, (4 mg, ip in corn oil). Values for animals are arranged in the same order as the male Cyp1a2−/− Hfe−/− Urod+/− group in Table 1.