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. Author manuscript; available in PMC: 2012 Sep 3.
Published in final edited form as: Mech Dev. 2011 Sep 3;128(7-10):442–456. doi: 10.1016/j.mod.2011.08.004

Figure 4.

Figure 4

A model for the origin of vertebrate STAT genes. A. The single STAT gene in the last common ancestor of all vertebrates. B–E. Sequential steps of genome duplication and gene loss (gray arrows). F. Current arrangements of STAT genes in today’s zebrafish and human genomes. See text for more explanation. Abbreviations: 1234, the ancestor of STAT1, STAT2, STAT3, and STAT4; 14, the ancestor of STAT1 and STAT4; 56, the ancestor of STAT5 and STAT6; divergence, the speciation event that separated the human and zebrafish lineages; In, chromosomal inversions; R1, R2, two sequential rounds of whole genome duplication at the base of vertebrate origins; roman numerals, zebrafish chromosomes; tandem, a tandem duplication event; TGD, teleost genome duplication event.