Table 1. Transcription factors and select other genes significantly affected by GSK3iXV treatment in E8.25 foregut endoderm.
Expression of these genes is changed >2-fold for 6 hour timepoint and >2.5-fold for 24 hour timepoint in EpCAM+ endoderm by treatment of E8.25 foregut endoderm with 10 mM GSK3iXV beads.
| Selected genes upregulated within 6 hours |
Selected genes upregulated between 6 and 24 hours |
Selected genes downregulated within 6 hours |
Selected genes downregulated between 6 and 24hours |
|---|---|---|---|
| Defcr-rs2 | Hoxd8 | Hhex | Rarb |
| Dkk4 | Hoxd9 | Wnt8a | Foxe1 |
| Evx1 | Hoxc9 | Hesx1 | Hoxb1 |
| Cdx2 | Hoxa7 | Gsc | Tbx1 |
| Sox17 | Fzd10 | Sox2 | Foxa1 |
| Axin2 | Sct | Pax1 | |
| Wnt6 | Sp7 | ||
| Cdx1 | T | ||
| Tcf7 | |||
| Klf5 | |||
| Lef1 | |||
| Sp6 | |||
| Tbx3 |