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. 2011 Nov 24;2:83. doi: 10.3389/fphys.2011.00083

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Copyright © 2011 van der Velden, Merkus, de Beer, Hamdani, Linke, Boontje, Stienen and Duncker.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Sarcomeric function. Force measurements were performed at a sarcomere length of 2.2 μm in Triton-permeabilized EPI and ENDO cells from six sham and six MI hearts. Force characteristics did not differ between EPI and ENDO cells within each group. (A) Maximal force (F_max) was significantly lower in ENDO cells from MI compared to sham, while passive force [(B) F_pas] was significantly higher in EPI cells from MI compared to sham. (C) In both EPI and ENDO cells, Ca²⁺-sensitivity (pCa₅₀) was significantly higher in MI than in sham. *P < 0.05, MI vs. sham.