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. 2011 Nov 24;2:83. doi: 10.3389/fphys.2011.00083

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Copyright © 2011 van der Velden, Merkus, de Beer, Hamdani, Linke, Boontje, Stienen and Duncker.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Dobutamine-induced changes in protein phosphorylation. Transmural samples were taken at baseline and after dobutamine stimulation from the same heart (six hearts in each group). Transmural biopsies were cut to obtain subepicardial (EPI) and subendocardial (ENDO) tissue samples. Dobutamine significantly increased phosphorylation of cardiac myosin binding protein C (cMyBP-C) to a similar extent in sham and MI myocardium. The dobutamine-induced increase in troponin I (cTnI) phosphorylation was larger in sham compared to MI myocardium for both EPI and ENDO tissue. A significant increase in myosin light chain 2 (MLC-2) phosphorylation was observed in sham myocardium upon dobutamine, which was not observed in MI samples. For all proteins no differences were observed between EPI and ENDO samples of the heart. ^#P < 0.05, effect dobutamine in two-way ANOVA.