Table 1.
Anatomical and hemodynamical data measured with closed-chest.
| SHAM (n = 12) | MI (n = 12) | |
|---|---|---|
| ANATOMICAL DATA | ||
| BW (kg) | 30 ± 1 | 30 ± 1 |
| LV weight (g) | 88 ± 5 | 102 ± 3* |
| LV weight/BW (g/kg) | 2.9 ± 0.1 | 3.5 ± 0.1* |
| LV end-diastolic area (mm2) | 913 ± 54 | 1342 ± 133* |
| LV end-systolic area (mm2) | 426 ± 37 | 830 ± 114* |
| 2D-Ejection fraction (%) | 53 ± 3 | 39 ± 4* |
| HEMODYNAMIC DATA | ||
| Cardiac output (L/min) | 3.7 ± 0.3 | 3.0 ± 0.1* |
| Heart rate (HR, bpm) | 112 ± 5 | 124 ± 12 |
| Mean aortic pressure (mmHg) | 92 ± 5 | 98 ± 4 |
| Mean pulmonary artery pressure (mmHg) | 18 ± 1 | 28 ± 2* |
| LVdP/dtmax (mmHg/s) | 2002 ± 119 | 1717 ± 68* |
| LVdP/dtmin (mmHg/s) | −2199 ± 164 | −1915 ± 104 |
| Tau (ms) | 34 ± 1 | 45 ± 4* |
| LV end-diastolic pressure (mmHg) | 6 ± 2 | 15 ± 2* |
n, Number of animals; BW, body weight; LV, left ventricle. *P < 0.05; MI vs. sham in one-tailed Student’s t-test.