Figure 3. Proportional level of mt.δ4977 ‘common deletion’ (CD) in homogenized skeletal muscle from HIV-infected subjects.
HIV+/NRTI+, HIV-infected, nucleoside analogue exposed; HIV+/NRTI−, HIV-infected, treatment-naïve. Dotted line represents lower threshold of assay. NRTI treated subjects showed significantly higher mean levels of CD than untreated subjects (HIV+/NRTI+ (mean ±SEM), −3.45 ±0.25 log10(/mtDNA); HIV+/NRTI−, −4.56 ±0.31 log10(/mtDNA); p=0.012). Box and whisker plot.