Fig 7 Trial sequential analysis for non-fatal myocardial infarction. Heterogeneity adjusted required information size of 63 446 participants calculated on basis of proportion of non-fatal myocardial infarction of 4.5% in conventional glucose control group, relative risk reduction of 10%, α=5%, β=20%, and I²=0%. Actually accrued No of participants was 27 958, 44% of required information size. Dashed red cumulative Z curve does not cross solid blue trial sequential monitoring boundaries for benefit or harm. Horizontal dotted green lines illustrate the traditional level of statistical significance (P=0.05)