Fig. 1.

Eiger-induced cell death is caspase-independent in Drosophila eyes. (A–G) Genetic interactions between the pan-caspase inhibitor p35 and Eiger, Reaper, or Hid. Note that the coexpression of p35 with Eiger did not significantly suppress the reduction of the adult eye size. (H–J) Ectopic expression of Eiger did not induce a significant increase in caspase 3-like activity. (K–N) Loss of the Drosophila initiator caspase, dronc, did not suppress the Eiger-induced eye reduction. The dronc-null mutant allele is described in ref. 49. In all images, anterior is to the left.