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Intracranial inoculation of EV71 transiently increased proinflammatory cytokines in mice, but not noradreanline. Seven-day-old ICR mice (n = 24) were intracranially inoculated with or without EV71/MP4 strain (4 x 105 PFU/mouse). Serum or plasma samples were collected at indicated post-inoculation time points. Concentrations of IL-6, IL-10, IL-13, and IFN-γ (A) and noradrenaline (B) were determined. Data represent means ± S.E.M.
