Table 1.
Baseline variables
| Lung Protective Ventilation N=430 | No Lung protective Ventilation N=955 | p | |
|---|---|---|---|
| Age, years | 48.5 ± 16.5 | 50.7 ± 16.4 | 0.024 |
| Sex, male | 282 (65.6) | 462 (48.4) | 0.001 |
| Race | 0.011 | ||
| White | 276 (64.2) | 662 (69.3) | |
| Black | 103 (24.0) | 163 (17.1) | |
| Other | 51 (11.9) | 130 (13.6) | |
| Body Mass Index, (kg/m2) | 27.6 ± 7.2 | 28.4 ± 7.3 | 0.04 |
| Height (cm) | 173.7 ± 10.3 | 168.0 ± 10.1 | 0.001 |
| Weight (kg) | 83.5 ± 22.8 | 80.1 ± 22.0 | 0.015 |
| SAPS II | 50.0 ± 13.9 | 47.9 ± 14.2 | 0.03 |
| Brussels organ failures | 1.93 ± 0.98 | 1.99 ± 0.97 | 0.21 |
| Brussels non-pulmonary organ failures | 0.99 ± 0.91 | 1.0 ± 0.92 | 0.34 |
| ARDS (PaO2/FiO2 <200) | 383 (89) | 821 (86) | 0.067 |
| ALI Risk Factor | |||
| Direct lung injury | 272 (69.7) | 566 (63.7) | 0.04 |
| Pneumonia | 197 (45.8) | 432 (45.2) | 0.86 |
| Sepsis | 85 (19.8) | 233 (24.4) | 0.062 |
| Aspiration | 75 (17.4) | 134 (14.0) | 0.10 |
| Trauma | 22 (5.1) | 71 (7.4) | 0.13 |
| Transfusion | 11 (2.6) | 19 (2.0) | 0.55 |
| Other | 40 (9.3) | 66 (6.9) | 0.13 |
| Co-Morbidities | |||
| Malignancy | 19 (4.4) | 42 (4.4) | 1.0 |
| AIDS | 40 (9.7) | 60 (6.4) | 0.04 |
| Dialysis | 2 (0.48) | 17 (1.8) | 0.076 |
| Diabetes | 71 (17.2) | 157 (16.7) | 0.87 |
| Mechanical ventilation parameters | |||
| Volume assist control mode | 406 (94.4) | 804 (84.2) | 0.001 |
| PaO2/FiO2 | 122 ± 55 | 131 ± 60 | 0.017 |
| Pplat (cm H2O) | 25.7 ± 7.2 | 26.8 ± 6.8 | 0.01 |
| PaCO2 (mm Hg) | 43.2 ± 11.1 | 38.3 ± 8.9 | 0.001 |
| PEEP (cm H2O) | 10.2 ± 4.3 | 9.2 ± 3.9 | 0.001 |
| Static compliance (cc/cmH2O) | 29.8 ± 34 | 31.0 ± 33.8 | 0.001 |
| Minute ventilation (L/minute) | 12.3 ± 3.7 | 12.3 ± 4.0 | 0.51 |
| Arterial pH | 7.34 ± 0.096 | 7.37 ± 0.092 | 0.001 |
| Radiographic Lung Injury Score | 3.8 ± 0.50 | 3.70 ± 0.58 | 0.002 |
| Serum Bicarbonate (mmol/L) | 21.6 ± 5.3 | 21.1 ± 5.6 | 0.11 |
| Duration Intubation prior to enrollment (days) | 1.1 ± 1.0 | 1.1 ± 1.2 | 0.48 |
| Duration ICU stay prior to enrollment (days) | 1.8 ± 1.9 | 1.6 ± 2.1 | 0.03 |
Abbreviations: kg: kilogram, m: meter, cm: centimeter, SAPS: Simplified Acute Physiology Score, mmol: millimoles, L: liter, NS: not-significant and not included in final adjusted model, PaO2/FiO2: ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, Pplat: static (plateau) airway pressure, PaCO2: partial pressure of arterial carbon dioxide, PEEP: positive end expiratory pressure, ICU: intensive care unit