Table 3. Adjusted* univariate models - Survivor-related factors associated with elevated% sibling scores (global severity index, somatization, depression, and anxiety).
| Sibling Factor | Global Severity Index | Somatization | Depression | Anxiety |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Survivor Diagnosis | ||||
| Bone cancer | 1.25 (0.59-2.50) | 1.53 (0.75-2.96) | 1.22 (0.67-2.11) | 1.74 (0.84-3.42) |
| Brain Tumor | 0.96 (0.47-1.84) | 0.86 (0.41-1.69) | 1.13 (0.67-1.86) | 0.94 (0.43-1.90) |
| Hodgkin Lymphoma | 1.16 (0.61-2.14) | 1.41 (0.78-2.52) | 0.83 (0.48-1.40) | 1.49 (0.78-2.78) |
| Non-Hodgkin Lymphoma | 1.31 (0.62-2.57) | 1.38 (0.67-2.66) | 1.15 (0.62-2.01) | 1.72 (0.82-3.39) |
| Neuroblastoma | 1.64 (0.68-3.52) | 0.58 (0.14-1.67) | 1.40 (0.67-2.69) | 1.42 (0.52-3.33) |
| Kidney | 0.64 (0.22-1.53) | 0.37 (0.09-1.04) | 0.63 (0.27-1.29) | 0.92 (0.34-2.11) |
| Soft tissue sarcoma | 1.11 (0.51-2.23) | 2.04 (1.10-3.70)** | 1.35 (0.77-2.29) | 1.32 (0.60-2.71) |
| Leukemia (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Survivor Treatment | ||||
| Chemo + RT + Surgery | 0.65 (0.34-1.34) | 0.85 (0.43-1.89) | 1.22 (0.65-2.56) | 1.03 (0.51-2.38) |
| Chemo + RT, no Surgery | 0.58 (0.24-1.39) | 0.87 (0.37-2.16) | 0.82 (0.36-1.94) | 0.74 (0.29-1.99) |
| RT + Surgery, no Chemo | 0.61 (0.26-1.46) | 0.59 (0.23-1.55) | 1.18 (0.54-2.69) | 0.76 (0.29-2.04) |
| Chemo + Surgery, no RT | 0.58 (0.26-1.32) | 0.80 (0.36-1.93) | 1.08 (0.52-2.41) | 0.71 (0.29-1.83) |
| Chemo or RT, no Surgery | 0.35 (0.08-1.16) | 0.29 (0.04-1.15) | 1.37 (0.55-3.46) | 0.33 (0.05-1.36) |
| Surgery only (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Survivor Health | ||||
| Fair/Poor | 1.42 (0.71-2.61) | 1.00 (0.46-1.91) | 2.18 (1.33-3.43)** | 1.00 (0.44-1.98) |
| Good/Very good/Excellent (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Survivor At Least 1 Chronic Health Condition | ||||
| Yes | 1.03 (0.69-1.55) | 1.01 (0.69-1.50) | 1.10 (0.80-1.54) | 1.24 (0.82-1.91) |
| No (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Survivor Psychological Distress## | ||||
| Yes | 2.16 (1.06-4.04)** | 0.91 (0.35-1.96) | 1.96 (1.14-3.22)** | 2.32 (1.05-4.57)** |
| No (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Sibling's Survivor Second Cancer | ||||
| Yes | 1.06 (0.37-2.40) | 1.86 (0.85-3.60) | 0.76 (0.30-1.63) | 1.85 (0.81-3.69) |
| No (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Sibling Age at Survivor Second Cancer | ||||
| 0-18 years | 0.77 (0.04-3.68) | 3.37 (0.97-8.99)** | 0.48 (0.03-2.27) | 1.75 (0.28-6.00) |
| 19-29 years | 0.50 (0.03-2.33) | 1.02 (0.17-3.38) | 0.60 (0.10-1.96) | 1.05 (0.17-3.46) |
| ≥30 years | 2.14 (0.50-6.36) | 1.76 (0.41-5.20) | 1.25 (0.30-3.62) | 3.19 (0.91-8.68)** |
| Survivor Without Second Cancer (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Sibling's Survivor Deceased | ||||
| Yes | 1.33 (0.70-2.33) | 1.27 (0.68-2.20) | 1.88 (1.19-2.86)** | 1.27 (0.65-2.26) |
| No (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
| Sibling Age at Survivor Death | ||||
| 0-18 years | 1.91 (0.83-3.83) | 1.76 (0.77-3.54) | 2.13 (1.11-3.78)** | 1.22 (0.42-2.80) |
| 19-29 years | 0.48 (0.08-1.57) | 0.88 (0.26-2.17) | 1.67 (0.80-3.14) | 1.01 (0.30-2.51) |
| ≥30 years | 1.98 (0.46-5.87) | 1.02 (0.16-3.54) | 1.74 (0.51-4.53) | 2.12 (0.49-6.30) |
| Survivor Alive (referent) | 1.00 | 1.00 | 1.00 | 1.00 |
**
P≤0.05
*
Adjusted for sibling-sex, sibling age at baseline, and sibling ethnicity.
%
Elevated scores correspond to a T score ≥ 63.
RT=radiation therapy
##
Psychological Distress= GSI or respective subscale elevation (e.g. for the outcome of sibling depression, survivor psychological distress refers to elevation on the depression subscale).