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. 2011 Nov;13(11):1081–1092. doi: 10.1593/neo.11794

Figure 4.

Figure 4

Transcriptional regulatory elements in HERV-K LTR. (A) Nucleotide nos. 1 to 968 of HERV-K LTR are shown according to the numbering in GenBank AF074086.2 (HML-2.HOM). Rectangular arrays indicate the major initiation sites (Inr460 and Inr826) determined by 5′ RACE. MITF-M-responsive sequences (MITF-1, -2, and -3) and 793TATA are highlighted (magenta). MITF-4 is underlined. A list of MITF binding core sequences used in the known MITF-induced genes is provided in reference [25]. The first nucleotide (no. 684) of the Del-7 region is marked by an arrowhead. (B) Proposed framework of HERV-K LTR. Inr826 defines the U3-R junction. Relative positions of Inr826, 793TATA, and the enhancer region formed by MITF-1, -2, and -3 are indicated. Inr460 is also indicated.