Table 1. Overview of knockdowns for TNF-induced necroptosis in L929 cells.
RNAi target | Role in TNF-induced necroptosis |
---|---|
Complex I | |
cIAP1 | Anti-necroptotic |
HOIL-1 HOIP | |
TAK1 NEMO | No apparent role or redundancy |
I and II | |
TRADD | No apparent role or redundancy |
RIP1 | Pro-necroptotic and anti-apoptotic |
Complex II | |
FADD caspase-8 c-FLIP | Anti-necroptotic |
RIP3 | Pro-necroptotic |
DUB | |
A20 | Anti-necroptotic |
CYLD | Pro-necroptotic |
Abbrevietion: DUB, deubiquitinating enzymes.
Knockdown of proteins involved in TNFR1 complex I or II.