Table 1. Overview of knockdowns for TNF-induced necroptosis in L929 cells.
| RNAi target | Role in TNF-induced necroptosis |
|---|---|
| Complex I | |
| cIAP1 | Anti-necroptotic |
| HOIL-1 HOIP | |
| TAK1 NEMO | No apparent role or redundancy |
| I and II | |
| TRADD | No apparent role or redundancy |
| RIP1 | Pro-necroptotic and anti-apoptotic |
| Complex II | |
| FADD caspase-8 c-FLIP | Anti-necroptotic |
| RIP3 | Pro-necroptotic |
| DUB | |
| A20 | Anti-necroptotic |
| CYLD | Pro-necroptotic |
Abbrevietion: DUB, deubiquitinating enzymes.
Knockdown of proteins involved in TNFR1 complex I or II.