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. 2011 Jun 13;121(7):2833–2844. doi: 10.1172/JCI43578

Figure 6. Progerin production is upregulated in cells with uncapped telomeres.

Figure 6

(A and B) qRT-PCR analysis of TRF2 and TRF2ΔBΔM (TRF2ΔΔ) cells with the progerin- or lamin A–specific primer pairs. Amounts of progerin (B) and LMNA (A) relative to ACTB are shown. (C) Western blotting analysis of progerin amount in normal fibroblasts infected with WT TRF2 or TRF2ΔBΔM. M, marker lane. (D) Immunofluorescence with anti-lamin A/C antibody (red) and anti-progerin (green) antibody. Nor, normal human fibroblasts. Scale bar: 10 μm.