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. 2011 Jun 13;121(7):2888–2897. doi: 10.1172/JCI45023

Figure 6. Relaxation and contraction of intrapulmonary arteries from WT and Mrp4–/– mice in normoxic or hypoxic conditions.

Figure 6

(A) Relaxation to carbamylcholine (0.01 to 1000 μM) in intrapulmonary arteries precontracted with either 10 μM or 30 μM of PGF2a in normoxic and chronic hypoxic mice, respectively (n = 8–13 rings, 4–5 mice and n = 10 rings, 6 mice, respectively). Relaxation is expressed as a percentage of the precontraction to PGF2a. Dose-dependent contraction to PGF2a (0.01 to 300 μM) (n = 8 rings, 3 mice in normoxia and n = 6 rings, 6 mice in chronic hypoxia) (**P < 0.001). (B) Comparison of the contraction to 10 μM phenylephrine (Phe) (n = 9–13 rings, 4–5 mice in normoxia and n = 16 rings, 6 mice in chronic hypoxia). (C) Comparison of the contraction to high potassium solutions (80 mM KCl) (n = 16 rings and 6 mice in normoxia and chronic hypoxia). (*P < 0.05).