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. 2011 Jun 13;121(7):2736–2749. doi: 10.1172/JCI45444

Figure 8. Mye-KO mice exhibit altered inflammatory and metabolic gene expression in tissues following HFD.

Figure 8

(A and B) Myeloid deficiency of KLF4 in HFD-mice affects transcription of many genes involved in nutrition uptake, β-oxidation, oxidative phosphorylation and inflammation in white adipose tissue (A) and skeletal muscle (B). n = 6 in each group. (C) Increased macrophage infiltration of white fat tissues and muscle tissues as determined by Mac-3 antibody staining. Original magnification, ×400. (D) Quantification of Mac-3 staining. n = 6 in each group. (E) Myeloid deficiency of KLF4 in HFD-fed mice affects expression of macrophage M1 and M2 genes in SVF. n = 6 in each group. *P < 0.05, Student’s t test. (F) Schematic of proposed mechanism. See text for details.