Figure 3. l-DOPA–induced diuresis and natriuresis were attenuated in ptAadc^–/– mice.

Three-month-old male mice were studied. l-DOPA induced significantly less increased urine volume and sodium excretion in ptAadc^–/– mice than in wild-type mice (urine volume, *P < 0.001 vs. basal wild type, ^†P < 0.01 vs. basal ptAadc^–/–, ^‡P < 0.001 vs. l-DOPA–treated wild type) (sodium excretion, *P < 0.005 vs. basal wild type, ^†P < 0.05 vs. l-DOPA–treated wild type) (n = 6 in each group).