Figure 5. Plasma aldosterone levels and renin activity were suppressed in ptAadc^–/– mice.

(A) Plasma aldosterone levels were significantly lower in ptAadc^–/– than in wild-type mice (*P < 0.001; n = 6). (B) PRA was lower in untreated ptAadc^–/– mice than in wild-type mice but increased more in ptAadc^–/– mice than in wild-type mice after hydralazine stimulation (*P < 0.01 vs. basal wild type, ^†P < 0.001 vs. basal ptAadc^–/–, ^‡P < 0.001 vs. hydralazine stimulated wild type; n = 6 in each group).