Figure 7. ptAadc^–/– mice developed salt-sensitive hypertension.

(A) MBP was similar between 3-month-old ptAadc^–/– mice and wild-type mice on a low-salt diet. Increasing dietary salt intake had no effect on MBP in wild-type mice but led to progressive increases in MBP in ptAadc^–/– mice (*P < 0.01 vs. wild type on a normal-salt diet, ^†P < 0.05 vs. wild type on a high-salt diet, ^‡P < 0.005 vs. ptAadc^–/– on a normal-salt diet; n = 9 in each group). (B) Dynamics of systolic, diastolic, and MBP measured by radiotelemetry from 8 to 12 days after surgery (n = 4). (C) MBPs measured by radiotelemetry from 8 to 12 days after surgery. (D) Male wild-type and ptAadc^–/– mice were fed an 8% high-salt diet for 4 weeks, and 24-hour urine was collected for measurement of F₂-isoprostanes (*P < 0.05; n = 6).