TABLE 5.
Associations between common haplotypes in SCD1 and MetS risk in the Costa Rican sample (n = 1410)1
| Haplotype | Frequency | PR | 95% CI |
P value | ||
| G-C-C-T-T-C-T2 | Total | 0.35 | 1.0 | — | — | — |
| A-T-T-G-T-C-T | 0.24 | 1.14 | 1.00 | 1.31 | 0.07 | |
| A-T-C-T-T-C-T | 0.10 | 1.18 | 0.98 | 1.41 | 0.08 | |
| G-C-C-T-T-C-T | Women | 0.36 | 1.0 | — | — | — |
| A-T-T-G-T-C-T | 0.23 | 1.37 | 1.14 | 1.66 | <0.01 | |
| A-T-C-T-T-C-T | 0.08 | 1.37 | 1.07 | 1.76 | 0.01 | |
| G-C-C-T-T-C-T | Men | 0.35 | 1.0 | — | — | — |
| A-T-T-G-T-C-T | 0.24 | 1.01 | 0.83 | 1.22 | 0.94 | |
| A-T-C-T-T-C-T | 0.10 | 1.08 | 0.84 | 1.38 | 0.57 | |
1
PR were estimated by use of log-Poisson regression model using the most common haplotype as the referent group; adjusted for individual admixture proportion and age. MetS, metabolic syndrome; PR, prevalence ratio; SNP, single nucleotide polymorphism.
2
The order of SNP in the haplotype is rs735877, rs1502593, rs11190483, rs3071, rs11557927, rs508384, and rs1393491.