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The neurotrophins BDNF and NT-3 have `yin-yang' regulatory effects on voltage-gated ion channel and synaptic protein composition in spiral ganglion neurons. In general, when one of the electrophysiologically-relevant proteins (described in the text) was up regulated by one neurotrophin, it was down regulated by the other. Kv1.1 and Kv4.2 were exceptions; only up regulation by the respective neurotrophins, BDNF and NT-3, was noted. Table from Flores-Otero et al., 2007.
