Figure 4.

Action potential latency and duration are prolonged differentially in apical, middle, and basal neurons after CdCl₂ application. (a) Representative whole-cell current clamp traces from apical, middle, and basal neurons exemplifying action potential latency at threshold before (black traces labeled with triangles) and after application of CdCl₂ (gray traces labeled with diamonds). (b) Individual latency measurements before and after CdCl₂ exposure. (c) Averaged measurements show significant increases in action potential latency for apex, middle, and base neuronal recordings after CdCl₂ application. (d) Change in latency before and after the CdCl₂ application. (e) Representative traces aligned at peak action potential voltage exemplifying action potential duration differences of apical, middle, and basal recordings before (black traces labeled with triangles) and after application of CdCl₂ (gray traces labeled with diamonds). (f) Individual duration measurement before and after CdCl₂ application. (g) Averaged measurements show significant differences in action potential duration for recordings made from apex, middle, and basal neurons exposed to CdCl₂. (h) Change in duration before and after CdCl₂ application.