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. 2011 Jul 1;121(8):3289–3305. doi: 10.1172/JCI46482

Figure 10. Parkinsonian locomotor deficits effectively treated by delivery of electrical current with adequate depolarization of STN neurons.

Figure 10

(A–D) Plots of the locomotor traces of control (A) and parkinsonian (B) rats and of parkinsonian rats receiving high-frequency stimulation (HFS) at 130 Hz (C) and low-frequency stimulation (LFS) at 30 Hz (D). (E–G) Different parameters of locomotor activities in normal and parkinsonian rats with and without HFS or LFS. The group of parkinsonian rats with HFS or that with LFS is compared with the control parkinsonian group (n = 6 for each group, *P < 0.05). (H–J) Administration of 30 Hz negative current stimulation with different pulse widths (1% SI = 333 μs, 10% SI = 3,333 μs, 50% SI = 16,667 μs, 99% SI = 33,000 μs). Significant improvement in locomotor parameters is obtained with 50% SI and 99% SI. n = 7; *P < 0.05, compared with sham stimulation. (K–M), Topical administration of 3 μM TTX into STN can also remedy locomotor deficits in parkinsonian rats (n = 5; *P < 0.05, rats with versus without TTX administration).