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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Drug Discov Today Dis Models. 2011 Spring;8(1):21–28. doi: 10.1016/j.ddmod.2011.06.002

Table I.

Representative Studies Implicating MMPs in Vascular Remodeling

Model Stimulus MMP Blockade Remodeling MMPs Investigated References
SHR Spontaneous Hypertension GM6001, EDTA, Doxycycline Rarefaction 2,9,7 [13]
2K1C Hypertensive Rat Renovascular hypertension Tempol Inward 2 [36]
2K1C Hypertensive Rat Renovascular Hypertension Doxycycline Inward 2,9,14 [25,35]
Rabbit Aorta In vivo Balloon Angioplasty Doxycycline Inward 2 [57]
Rat Carotid Artery In vivo Balloon Angioplasty GM6001 Neointima Gelatinases [54]
Rat Carotid Artery In vivo Balloon Angioplasty Neointima 1,2,9 [67]
Rat Carotid Artery In vivo Balloon Angioplasty Batimastat, RGD peptide Inward 2 [56]
Rat Carotid Artery In vivo Balloon Angioplasty Doxycycline Neointima 2,9 [55]
Rat Carotid Artery In vivo Balloon Angioplasty GM-6001 Neointima Not specified [68]
Pig iliac Artery In vivo Balloon Angioplasty Batimastat Inward Not specified [69]
Pig iliac/femoral Artery In vivo Balloon Angioplasty Marimastat Inward Not specified [70,71]
L-NAME Hypertensive Rat In vivo L-NAME Doxycycline Inward 2 [72]
Rat Mesenteric Artery Ligation In vivo High Flow L-NAME, Doxycycline Outward 9 [73]
Mouse Carotid Artery In vitro Ang-II MMP-9 KO Mouse Outward 2,9 [26]
Mouse Carotid Artery In vitro High Flow Doxycycline, SB-3CT, MMP-9 and MMP-12 KO Mouse Outward 2,9,12 [32]
Mouse Carotid Artery In vitro Transmural Pressure FN-439 Outward 2,9 [27]

SHR, spontaneous hypertensive rats; Ang-II, angiotensin-II; 2K1C, two-kidneys one-clip; L-NAME, NG-nitro-L-arginine-methyl-ester; KO, knockout; SB-3CT and FN-439 are selective MMP inhibitors.