Table I.
Model | Stimulus | MMP Blockade | Remodeling | MMPs Investigated | References |
---|---|---|---|---|---|
SHR | Spontaneous Hypertension | GM6001, EDTA, Doxycycline | Rarefaction | 2,9,7 | [13] |
2K1C Hypertensive Rat | Renovascular hypertension | Tempol | Inward | 2 | [36] |
2K1C Hypertensive Rat | Renovascular Hypertension | Doxycycline | Inward | 2,9,14 | [25,35] |
Rabbit Aorta | In vivo Balloon Angioplasty | Doxycycline | Inward | 2 | [57] |
Rat Carotid Artery | In vivo Balloon Angioplasty | GM6001 | Neointima | Gelatinases | [54] |
Rat Carotid Artery | In vivo Balloon Angioplasty | Neointima | 1,2,9 | [67] | |
Rat Carotid Artery | In vivo Balloon Angioplasty | Batimastat, RGD peptide | Inward | 2 | [56] |
Rat Carotid Artery | In vivo Balloon Angioplasty | Doxycycline | Neointima | 2,9 | [55] |
Rat Carotid Artery | In vivo Balloon Angioplasty | GM-6001 | Neointima | Not specified | [68] |
Pig iliac Artery | In vivo Balloon Angioplasty | Batimastat | Inward | Not specified | [69] |
Pig iliac/femoral Artery | In vivo Balloon Angioplasty | Marimastat | Inward | Not specified | [70,71] |
L-NAME Hypertensive Rat | In vivo L-NAME | Doxycycline | Inward | 2 | [72] |
Rat Mesenteric Artery Ligation | In vivo High Flow | L-NAME, Doxycycline | Outward | 9 | [73] |
Mouse Carotid Artery | In vitro Ang-II | MMP-9 KO Mouse | Outward | 2,9 | [26] |
Mouse Carotid Artery | In vitro High Flow | Doxycycline, SB-3CT, MMP-9 and MMP-12 KO Mouse | Outward | 2,9,12 | [32] |
Mouse Carotid Artery | In vitro Transmural Pressure | FN-439 | Outward | 2,9 | [27] |
SHR, spontaneous hypertensive rats; Ang-II, angiotensin-II; 2K1C, two-kidneys one-clip; L-NAME, NG-nitro-L-arginine-methyl-ester; KO, knockout; SB-3CT and FN-439 are selective MMP inhibitors.