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Gene expression and Transcription factor activity based gene Regulatory Network (GTRNetwork) framework. GTRNetwork algorithm has two steps. Step 1 (Yellow) take input of transctriptome data, predict transcription factor activities (TFAs) of TFs from known TF-Gene Network Topology. Step 2 (Purple) take the input of trancriptome data and introduce the predicted TFAs from step 1 to reconstruct gene regulatory network use score based network reconstruction methods.
