Table 2.
Valid search of 12 predicted new links using literature.
| TF | Gene | Supporting Evidence |
|---|---|---|
| DicA | insD | TF binding site verified (RegulonDB) [34] |
| DicA | intQ | TF binding site verified (RegulonDB) [34] |
| DicA | ydfE | TF binding site verified (RegulonDB) [34] |
| DcuR | pepE | Involved in anaerobic respiration related process (EcoCyc [37]) |
| Fur | ybdB | ybdB (entH) is proposed to be regulated by Fur (EcoCyc [37]) |
| Fur | yncE | yncE is de-repressed by Fur [41] |
| IscR | fdx | Some evidence that the Fdx functions as an intermediate site for Fe-S cluster assembly [42] |
| IscR | hscA | HscA is required for the assembly of Fe-S clusters [43,44] |
| IscR | hscB | HscB is a co-chaperone that stimulates HscA (Hsc66) ATPase activity [44] |
| IscR | iscX | Possibly involved in Fe-S cluster biogenesis [43] |
| SgrR | sroA | TF binding site verified (RegulonDB)[34] |
New regulatory links of E. coli predicted in a reconstructed gene regulatory network of size of 200 links (includes 16 potential new regulatory links).