Table 3.
High Frequency Copy Number Alterations in Subtypes of Breast Cancer*
| Chromosomal arm | ER-positive (n=154) | ER-negative (n=105) | HER2-positive (n=35) | Triple Negative (n=65) |
|---|---|---|---|---|
| 1p | Gain | Gain | Gain/Loss | |
| 1q | Gain | Gain | Gain/Loss | Gain |
|
| ||||
| 2p | Loss | |||
| 2q | Loss | |||
|
| ||||
| 3p | Loss | Loss | ||
| 3q | Loss | |||
|
| ||||
| 4p | Loss | Loss | Loss | |
| 4q | Loss | |||
|
| ||||
| 5p | ||||
| 5q | Loss | Loss | ||
|
| ||||
| 6p | Loss | |||
| 6q | Loss | |||
|
| ||||
| 7p | Loss | |||
| 7q | Loss | |||
|
| ||||
| 8p | Loss | Loss | Loss | Loss |
| 8q | Gain | Gain | Gain/Loss | Gain |
|
| ||||
| 9p | Loss | |||
| 9q | Loss | |||
|
| ||||
| 10p | Loss | |||
| 10q | Loss | Loss | Loss | Loss |
|
| ||||
| 11p | Loss | Loss | Loss | |
| 11q | Loss | Loss | Loss | Loss |
|
| ||||
| 12p | Loss | |||
| 12q | Loss | Loss | Loss | Loss |
|
| ||||
| 13q | Loss | |||
|
| ||||
| 14q | Loss | Loss | ||
|
| ||||
| 15q | Loss | Loss | ||
|
| ||||
| 16p | Loss | |||
| 16q | Loss | Loss | Loss | Loss |
|
| ||||
| 17p | Loss | |||
| 17q | Gain/Loss | |||
|
| ||||
| 18p | ||||
| 18q | Loss | |||
|
| ||||
| 19p | Loss | |||
| 19q | Loss | |||
|
| ||||
| 20p | Loss | Loss | ||
| 20q | Loss | |||
|
| ||||
| 21p | ||||
| 21q | ||||
|
| ||||
| 22p | ||||
| 22q | Loss | Loss | ||
|
| ||||
| Xp | ||||
| Xq | Loss | |||
High-frequency CNA (weighted fraction >40% of tumors) mapped by chromosomal arm.