Table 1.
Strategy | Corr | MAF | Method | |||||
---|---|---|---|---|---|---|---|---|
LR | FPM | TPM | Lasso | Enet | GRLR | |||
I | 0.0 | 0.10 | 0.196 | 0.206 | 0.198 | 0.210 | 0.226 | 0.196 |
0.30 | 0.638 | 0.620 | 0.602 | 0.688 | 0.670 | 0.650 | ||
0.50 | 0.792 | 0.734 | 0.730 | 0.790 | 0.828 | 0.826 | ||
0.2 | 0.10 | 0.184 | 0.216 | 0.194 | 0.194 | 0.204 | 0.206 | |
0.30 | 0.712 | 0.642 | 0.622 | 0.690 | 0.726 | 0.704 | ||
0.50 | 0.860 | 0.794 | 0.788 | 0.902 | 0.888 | 0.870 | ||
II | 0.0 | 0.10 | 0.008 | 0.078 | 0.070 | 0.032 | 0.052 | 0.124 |
0.30 | 0.122 | 0.266 | 0.252 | 0.340 | 0.392 | 0.558 | ||
0.50 | 0.354 | 0.304 | 0.306 | 0.526 | 0.624 | 0.768 | ||
0.2 | 0.10 | 0.018 | 0.088 | 0.064 | 0.066 | 0.078 | 0.126 | |
0.30 | 0.202 | 0.296 | 0.300 | 0.364 | 0.458 | 0.608 | ||
0.50 | 0.400 | 0.370 | 0.360 | 0.628 | 0.690 | 0.806 |
Results of power simulations for six methods under Scenario (A) (two causal SNPs). Two definitions of testing success, Strategy I (requiring that at least one of the two SNPs is significant) and Strategy II (requiring significance at both SNPs), are applied in comparisons; The number of replication runs is 500 for all the simulations. Corr = correlation coefficient; MAF = minor allele frequency.