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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Cell Physiol. 2012 Jun;227(6):2470–2479. doi: 10.1002/jcp.22982

Fig. 4. Dual functional effects of INSM1 and the ITFs.

Fig. 4

(A) INSM1 inhibits dexamethasone induced exocrine amylase expression. In the presence of dexamethasone (Dex+), Ad-INSM1 inhibits 50% of amylase expression as compared to the control Ad-LacZ group. The p value represents as **<0.01. The three ITFs inhibit 100% of the dexamethasone induced amylase expression. (B) Different titers of adenovirus showed variable inhibitory activities on amylase expression with the maximal inhibition at 40:1. (C) The three ITFs increase insulin expression dramatically as compared with Ad-INSM1 alone. (D) The three ITFs require 72 h to achieve maximal insulin expression. The p values represent as *<0.05 and **<0.01.