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. Author manuscript; available in PMC: 2012 Nov 28.

Published in final edited form as: Vaccine. 2011 Sep 9;29(51):9563–9572. doi: 10.1016/j.vaccine.2011.08.089

HAI titers after immunization with Fluzone formulated with squalene, perfluorocarbon, soybean, or Miglyol 810 oil emulsion. BALB/c mice were immunized and then serum HAI titers determined four weeks after boosting. (a) HAI titers against the A/Solomon Islands/3/2006 (H1N1) component of Fluzone. (b) HAI titers against the A/Wisconsin/67/2005 (H3N2) component of Fluzone. (c) HAI titers against the heterologous A/Brisbane/59/07 influenza strain. (d) HAI titers against the heterologous A/Uruguay/716/07 influenza strain. Data are shown as the (Log₂) titer for each individual animal, with the geometric mean and SEM represented. * = p-value < 0.05 versus immunization with vaccine alone; # = p-value < 0.05 versus immunization with the vaccine containing the perfluorocarbon emulsion; % = p-value < 0.05 versus immunization with the vaccine containing the soybean emulsion; ^ = p-value < 0.05 versus immunization with the vaccine containing the Miglyol emulsion.

HAI titers after immunization with Fluzone formulated with squalene, perfluorocarbon, soybean, or Miglyol 810 oil emulsion. BALB/c mice were immunized and then serum HAI titers determined four weeks after boosting. (a) HAI titers against the A/Solomon Islands/3/2006 (H1N1) component of Fluzone. (b) HAI titers against the A/Wisconsin/67/2005 (H3N2) component of Fluzone. (c) HAI titers against the heterologous A/Brisbane/59/07 influenza strain. (d) HAI titers against the heterologous A/Uruguay/716/07 influenza strain. Data are shown as the (Log₂) titer for each individual animal, with the geometric mean and SEM represented. * = p-value < 0.05 versus immunization with vaccine alone; # = p-value < 0.05 versus immunization with the vaccine containing the perfluorocarbon emulsion; % = p-value < 0.05 versus immunization with the vaccine containing the soybean emulsion; ^ = p-value < 0.05 versus immunization with the vaccine containing the Miglyol emulsion.