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Representative radioligand competition displacement curves for the primary amine tryptamine at WT vs. S3.36A and Y7.43A (inset) point-mutated 5-HT2C receptors. Data show means and S.E.M. from an individual experiment of percent specific binding of [3H]-mesulergine. The curves for the point-mutated receptors are significantly (P < 0.05) shifted to the right compared to the WT receptor.
