Table 3.
Top associated markers based on imputed allelic frequencies
| SNP | CHR | Position | Empiric | Imputed | MAF(emp) | MAF(imp) | STATUS |
|---|---|---|---|---|---|---|---|
| rs2000816 | 11 | 84151075 | 0,2382 | 1,57E-30 | 0,50 | 0,49 | Discordant |
| rs4143896 | 14 | 41379353 | 0,4551 | 1,06E-19 | 0,50 | 0,49 | Discordant |
| rs4982270 | 14 | 34950569 | 0,0853 | 5,72E-17 | 0,50 | 0,49 | Discordant |
| rs10152907 | 15 | 52679008 | 0,3110 | 2,30E-15 | 0,50 | 0,50 | Discordant |
| rs12900200 | 15 | 99971327 | 0,0394 | 2,80E-15 | 0,49 | 0,49 | Discordant |
| rs35143 | 16 | 63543734 | 0,8364 | 3,62E-15 | 0,50 | 0,49 | Discordant |
| rs2572406 | 8 | 11129662 | 0,0291 | 6,78E-15 | 0,49 | 0,48 | Discordant |
| rs2996005 | 1 | 217884996 | 0,0010 | 5,61E-14 | 0,48 | 0,48 | Discordant |
| rs696891 | 5 | 60940318 | 0,4430 | 9,85E-14 | 0,50 | 0,49 | Discordant |
| rs4506565 | 10 | 114746031 | 6,02E-13 | 1,38E-12 | 0,35 | 0,35 | Concordant |
The column "Position" refers to the chromosomal position of the marker based on the reference genome (Hg18). The columns Empiric and Imputed organize the observed p values for the association with the diabetes phenotype based on directly genotyped and imputed allelic frequencies, respectively. The columns MAF(emp) and MAF(imp) refers to the minor allele frequency determined by allelic frequencies determined by direct genotyping (emp) and imputed (imp). The column STATUS describes if there is a concordance between association statistics based on allelic frequencies determined by both measures using a pre defined stringent significance threshold (10 -8).