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Workflow used in the present study. (A) The PPI and DNA methylation data sources used in the construction of WHPN. (B) The acquirement of seed genes and the construction of CASN. (C) Analysis of the topological features of WHPN and CASN. (D) Analysis of the optimized genes using the GO and KEGG enrichment analysis, SAM and PubMed co-citations.
