Table 2.
Comparison of two consecutive periods of nerve stimulation in control preparations
| Tissue (nCi × 103/100 mg) (a) | Fraction released per shock (× 10−5) (b) | Metabolism (% of the total) (c) | ||||
|---|---|---|---|---|---|---|
| NA | CDA | NMN | OMDA | |||
| 1st Stim | 505 ± 0·85 | 1·60 ± 0·30 | 74 ± 2·7 | 6·9 ± 1 | 11 ± 1·3 | 7·3 ± 2·0 |
| 2nd Stim | 4·47 ± 0·70 | 1·46 ± 0·22 | 75 ± 3·1 | 6·2 ± 0·9 | 12 ± 1·6 | 6·3 ± 1·0 |
| Ratio | ||||||
 |
0·89 ± 0·04 | 0·93 ± 0·04 | 1·01 ± 0·03 | 0·94 ± 0·15 | 1·09 ± 0·07 | 1·08 ± 0·3 |
(a) Total radioactivity in the tissue. (b) Fraction of the total radioactivity released by nerve stimulation. (c) Percentage of [3H]-noradrenaline and [3H]-metabolites in overflow elicited by nerve stimulation. NA (noradrenaline); CDA (catechol-deaminated): [DOPEG (3,4 dihydroxyphenylglycol) and DOMA (3,4 dihydroxymandelic acid)]; NMN (normetanephrine); OMDA (O-methylated-deaminated): [MOPEG (3-methoxy-4-hydroxyphenylglycol) and VMA (3-methoxy-4-hydroxymandelic acid)]. (d) Ratio between second stimulation (2nd Stim) and first stimulation (1st Stim). Results are mean values ± s.e. of the mean for four experiments.