Fig. 4.

Results of a single experiment showing variations in the magnitude and relay of the responses to bradykinin injections of 0·1, 0·5 and 2·0 μg by indomethacin treatment (left hand group) and the mean (+s.e.m.) delay time in seconds to the start of the response in mmHg (left hand scale) and the thin black bars inside the broad ones represent the delays in seconds (right hand scale). Treatment with indomethacin (2 mg/kg i.v.) reduced the pressor effects and increased the delays. Infusion into the spleen of prostaglandin E₁ (200 ng/min) after indomethacin increased the values towards pretreatment levels.