Figure 2.

Inhibition of adenosine diphosphate (ADP)-induced thrombus formation in electrically damaged arterioles (40 to 80 μm) by increasing concentrations of prostacyclin (PGI₂) infused into the Krebs solution superfusing the hamster cheek pouch microcirculation. Inhibition is measured as a reduction in total thrombus time (see text) compared with control values. Each point is the mean of 4–7 experiments and the bars represent ± 1 s.e. mean. The straight line was fitted to the log dose-response curve by regression analysis. There is a highly significant linear regression (P > 0.001) and there is no significant deviation from linearity. NS, P > 0.01; *P < 0.0025, **P < 0.0005.