Table 3.
Relationships between CAIX and HIF-1α & clinicopathological variables
| Characteristic | No | No (%) stained for CAIX | p-value | No (%) stained for HIF-1α | p-value |
|---|---|---|---|---|---|
| Relapse/metastases | |||||
| Present | 8 | 4 | > 0.99 | 6 | 0.49 |
| Absent | 62 | 40 (65%) | 59 (95%) | ||
| Chemotherapy status | |||||
| Pre-CT | 22 | 16 (73%) | 0.47 | 20 (91%) | 0.29 |
| Post-CT | 40 | 24 (60%) | 39 (98%) | ||
| Stage Post-CT | |||||
| 1 | 14 | 9 (64%) | 0.85 | 14 (100%) | † |
| 2 | 13 | 7 (54%) | 13 (100%) | ||
| 3/4/5 | 13 | 8 (62%) | 12 (92%) | ||
| Risk group Post-CT | |||||
| High-risk | 5 | 2 | 0.37 | 5 | > 0.99 |
| Low/Intermediate risk | 35 | 22 (63%) | 34 (97%) | ||
| Histological type Post-CT | |||||
| Blastemal | 8 | 3 | † | 8 | † |
| Epithelial/Stromal | 10 | 9 (90%) | 10 (100%) | ||
| Mixed | 16 | 8 (50%) | 15 (94%) | ||
| Regressive | 6 | 4 | 6 | ||
| *Size (cm) Post-CT | > 0.99 | 0.45 | |||
| ≤9 | 22 | 13 (59%) | 22 (100%) | ||
| > 9 | 18 | 11 (61%) | 17 (94%) | ||
| **Weight (g) Post-CT | |||||
| ≤299 | 20 | 7 (35%) | 0.057 | 17 (85%) | > 0.99 |
| > 299 | 20 | 14 (70%) | 17 (85%) |
CT - chemotherapy, * size - 9 cm is the median size, **weight - 299 g is the median weight of total nephrectomy specimens. In 3 cases weight was unavailable, while 2 were partial nephrectomies.
†expected frequencies too small to do χ2-test
8 WT samples obtained from metastatic sites in addition to their primary tumours. Repeated samples from the same patient were regarded as independent samples in these comparisons.