Table 1.
Bloodstream bacterial isolates in clinical trials enrolling neutropenic adults between 1998 and 2009
| Carratala et al. Arch Intern Med 1998 [46] | Gruson et al. Eur Respir J 1999 [47] | Feld et al. J Clin Oncol 2000 [26] | Regazzoni et al. Intensive Care Med 2003 [48] | Harter et al. Bone Marrow Transplant 2006 [25] | Klastersky et al. Int J Antimicrob Agents 2007 [49] | Metallidis et al. Eur J Intern Med 2008 [50] | De La Rubia et al. Biol Blood Marrow Transplant 2009 [51] | |
|---|---|---|---|---|---|---|---|---|
| No. of patients | 39 | 38 | 411 | 62 | 161 | 2142 | 75 | 428 |
| No. of organisms | 43 | 5 | 93 | 16 | 96 | 556 | 13 | 125 |
| Gram-positive organisms | 18 (41.9) | 4 (80) | 41 (44.1) | 7 (43.7) | 70 (72.9) | 353 (63.5) | 6 (46.1) | 81 (64.8) |
| Staphylococcus spp | 3 (7) | 3 (60) | 13 (14) | 2 (12.5) | 52 (54.5) | 187 (33.6) | 6 (46.1) | 56 (44.8) |
| Streptococcus spp | 15 (34.9) | 1 (20) | 27 (29) | 4 (25) | 15 (15.6) | 114 (20.5) | - | 10 (8) |
| Other | - | - | 1 (1.1) | 1 (6.2) | 3 (3.1) | 52 (9.4) | - | 15 (12) |
| Gram-negative organisms | 25 (58.1) | 1 (20) | 52 (55.9) | 9 (56.3) | 26 (27.1) | 203 (36.5) | 7 (53.9) | 44 (35.2) |
| Enterobacteriaceae | 6 (14) | - | 42 (45.2) | 6 (37.5) | 22 (23) | 123 (22.1) | 4 (76.9) | - |
| P. aeruginosa | 17 (39.5) | 1 (20) | 6 (6.5) | 2 (12.5) | 3 (3.1) | 49 (8.8) | 2 (15.3) | - |
| Other | 2 (4.6) | - | 4 (4.3) | 1 (6.3) | 1 (1) | 31 (5.6) | 1 (7.7) | - |