Table 1.

Studies that have reported alterations in sublingual microcirculation in patients with severe sepsis and septic shock

Reference	No. of patients	Intervention
De Backer et al. AJRCCM 2002	50	Topical acetylcholine
Spronk et al. Lancet 2002	6	Nitroglycerin
Sakr et al. CCM 2004	49	Sequential assessment
De Backer et al. CCM 2006	22	Dobutamine
De Backer et al. CCM 2006	40	Activated protein C
Creteur et al. ICM 2006	18	Dobutamine
Boerma et al. CCM 2007	23	Sequential assessment
Trzeciak et al. Ann Emerg Med 2007	26	None
Sakr et al. CCM 2007	35	Transfusions
Trzeciak et al. ICM 2008	33	Goal directed therapy
Boerma et al. ICM 2008	35	None
Jhanji et al. ICM 2009	16	Norepinephrine
Dubin et al. Crit Care 2009	20	Norepinephrine
Buchele et al. CCM 2009	20	Hydrocortisone
Boerma et al. CCM 2010	70	Nitroglycerin
Ospina et al. ICM 2010	60	Fluids
Spanos et al. Shock 2010	48	None
Pottecher et al. ICM 2010	25	Fluids
Morelli et al. Crit Care 2010	40	Levosimendan
Ruiz et al. Crit Care 2010	12	High flow hemofiltration
Dubin et al. J Crit Care 2010	20	Fluids
Morelli et al. ICM 2011	20	Terlipressin