Table 3.
Cellular Stress Network coverage statistics for the test data set comparisons based on GSE18344 data
| Comparison | WT 1d vs sham | Nrf2 KO 1d vs sham | Nrf2 KO 1d vs WT 1d |
|---|---|---|---|
| State Changes (SCs) | 81 | 113 | 45 |
| Significant Cellular Stress Network Hypotheses | 39 | 47 | 23 |
| SCs Explained by Network | 67/81 (83%) | 75/113 (66%) | 40/45 (89%) |
| SCs Explained by Nfe2l2 | 29/81 (36%) | 20/113 (18%) | 31/45 (69%) |
| SCs Explained by Nfe2l2 or Keap1 | 37/81 (46%) | 27/113 (24%) | 36/45 (80%) |
SCs = mRNA State Changes; hypotheses - network model nodes predicted to have significantly increased or decreased activity by Reverse Causal Reasoning (RCR) on the SCs for each test data set comparison.