Table 3.

Symptoms considered typical for MCA by the members

Symptom(s)	Consensus level
Flushing	95%
Pruritus	90%
Urticaria	85%
Angioedema	75%
Nasal congestion	90%
Nasal pruritus	90%
Wheezing	70%
Throat swelling	85%
Headache	90%
Hypotension	95%
Diarrhea	90%

In order to count as cocriterion of MCA, these symptoms need to be recurrent or permanent, cannot be explained by other known disorders/conditions (other than MCA), and require a therapeutic intervention. Moreover, apart from these symptoms, additional clinical and laboratory criteria have to be fulfilled for the condition/reaction to be considered as MCA.