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. 2011 Sep 7;4:327. doi: 10.1186/1756-0500-4-327

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Copyright ©2011 Combarros et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genes related with the tau protein phosphatase-2A (PP2A) pathway. PP2A dephosphorylates tau and is composed of an structural subunit A, a catalytic subunit alpha (PPP2CA) and a regulatory subunit B alpha (PPP2R2A). The peptidyl-prolyl cis/trans isomerase PIN1 binds to tau and facilitates PP2A activity, whereas ANP32A inhibits PP2A activity. Methylation by the leucine carboxyl methyltransferase-1 (LCMT1) increases PP2A activity, and demethylation by protein phosphatase methylesterase-1 (PPME1) reduces PP2A activity.