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Effect of intravenous pre-administration of cefmetazole or cefazolin on [3H]PGE2 elimination from the brain in LPS-treated mice. Cefmetazole (200 mg/kg), cefazolin (200 mg/kg) or Ringer-HEPES (control) was administered intravenously 15 min prior to administration of [3H]PGE2 in LPS-treated mice. The 100-BEI value was determined 40 min after intracerebral microinjection of [3H]PGE2. Each column represents the mean ± S.E.M. (n = 3). *p < 0.05, significantly different from control.
