Table 2.
Effects of blockers of adenosine A1, A2A, A2B, and A3 receptors on relaxations evoked by 5′-N-ethylcarboxamidoadenosine (NECA, 0.1–300 μM) in the pig prostatic small arteries
| NECA | ||||
|---|---|---|---|---|
| n | It (mN) | pD2 | Emax (%) | |
| Control | 8 | 5.6 ± 1.1 | 6.0 ± 0.1 | 100 ± 0 |
| DPCPX (0.1 μM) | 8 | 4.9 ± 1.1 | 6.0 ± 0.1 | 100 ± 0 |
| Control | 8 | 6.3 ± 1.0 | 5.2 ± 0.1 | 78.4 ± 6.5 |
| ZM241385 (0.1 μM) | 8 | 7.0 ± 1.2 | 4.3 ± 0.1** | 69.1 ± 8.8 |
| Control | 6 | 6.2 ± 1.3 | 4.6 ± 0.1 | 72.8 ± 5.0 |
| PSB1115 (0.1 μM) | 6 | 6.5 ± 1.7 | 4.8 ± 0.1 | 80.8 ± 5.9 |
| Control | 6 | 2.7 ± 1.2 | 5.5 ± 0.2 | 90.8 ± 3.1 |
| MRS1220 (10 μM) | 6 | 2.3 ± 1.0 | 5.4 ± 0.2 | 98.1 ± 1.4 |
Results are expressed as mean ± s.e.m. of n arteries. pD2 = −log EC50, where EC50 is the concentration of agonist producing 50% of the Emax
It initial tension; Emax is the maximal relaxation, expressed as a percentage of the noradrenaline-induced contraction
**P < 0.01 versus control (paired t test)